160.21(2)(b)2.2. The regulatory agency may establish by rule additional points of standards application which the regulatory agency determines are necessary to protect future groundwater uses and the public interest in the waters of the state. 160.21(2)(c)(c) If facilities are subject to regulation under chs. 283 or 289 to 292, the department shall develop by rule and utilize points of standards application for purposes of facility design, the review of facility performance and enforcement as follows: 160.21(2)(c)1.1. Rules promulgated by the department under s. 289.05 (1) relating to facility design shall establish design criteria which ensure compliance with s. 160.19 (2) at any point of present groundwater use, at property boundaries and at any point beyond a 3-dimensional design management zone within property boundaries established under general criteria specified by rule and applied to individual facilities. 160.21(2)(c)2.2. The department shall consider any point at which groundwater is monitored and at which a preventive action limit is exceeded a point of standards application for purposes of facility performance review, including investigations and evaluation of specific sites. If the point is within the design management zone, the department shall evaluate the location of the point, specific characteristics of the site, the nature of the substance involved and the likelihood of substance migration in assessing the need for response activities. 160.21(2)(c)3.3. The department shall establish the point of standards application for enforcement standards at any point of present groundwater use, at property boundaries and at any point beyond a 3-dimensional design management zone within property boundaries established under general criteria specified by rule and applied to individual facilities. 160.21(2)(d)(d) The department shall establish criteria for design management zones by rule for the facilities specified under par. (c). The rule shall take into account different types of facility designs. The design management zone which is applied to a facility utilizing the criteria in the rule may be adjusted based on the following factors: 160.21(2)(d)6.6. Present and anticipated future uses of land and groundwater; 160.21(2)(d)8.8. Depth, direction and velocity of groundwater and other hydrogeologic factors; or 160.21(2)(d)9.9. Likely methods for abatement if an enforcement standard is exceeded. 160.21(2)(e)(e) The department and each regulatory agency shall enter into a memorandum of understanding setting forth the criteria for acceptable monitoring wells and sample handling for the point of standards application. 160.21(3)(3) Responses may include remedial actions, revisions of rules or criteria on facility design, location and management practices, prohibition of an activity or practice or closure of a facility. Remedial actions for a specific site may include, but are not limited to, investigations, relocation, prohibition of activities or practices which use or produce the substance, closure of a facility, revisions of operational procedures, monitoring or, if only a preventive action limit is attained or exceeded, no remedial action. Responses may vary depending on the type and age of the facility, the hydrogeological conditions of the site and the cost effectiveness of alternative responses that will achieve the same objectives under the conditions of the site. Responses shall take into account the background water quality at the site, the uses of the aquifer, the degree of risk, the validity of the data and the probability of whether, if a preventive action limit is exceeded, the enforcement standard will be exceeded at the point of standards application. In requiring a remedial action for a specific site, the regulatory agency shall use the authority and existing protections, including, but not limited to, due process provisions in other applicable statutes. 160.21(4)(4) In setting forth the range of responses and providing for implementation of appropriate responses under the rules promulgated under subs. (1) and (3), the regulatory agency shall consider, where applicable, the following: 160.21(4)(a)(a) Risk-benefit considerations including, but not limited to: 160.21(4)(a)1.1. Uses and substances alternative to the present use of the particular substance. 160.21(4)(a)2.2. Risks and benefits of the alternative uses or substances. 160.21(4)(a)3.3. Reliability and comprehensiveness of the information available for assessing such risks and benefits. 160.21(4)(b)(b) Hydrogeological considerations including, but not limited to: 160.21(4)(c)(c) Management and practice considerations including, but not limited to: 160.21(4)(c)2.2. The geographic extent of the substance if detected in groundwater and the size of the population affected.